I have been listening to this audio book – Lifespan: Why We Age And Why We Don’t Have To – by Professor David A. Sinclair.
If you listen to the audio book, the book’s accompanying PDF will be helpful.
To get you interested in the topic, you can start with this introductory video by NPR.
Professor David Sinclair
He knows body hacks, and very knowledgable with the science aspect. He has access to Harvard labs!
Check out Joe Rogan interview. He is 50 year old, but looks like 30!
Nicely said by his 80-year-old father, who is fitter than most 30-year-old.
This is what longer life is all about -— being around for your children’s important moments.
Me too. I want to live longer, for my children.
That’s a good motivation.
His Tips
Other than exercises in the gym, he also take:
- Metformin, also known as glucophage (2 x 500 mg/d for borderline high blood sugar)
- Exforge to lower blood pressure
- Lipitor, a statin to lower cholesterol (20 mg/d)
- An NAD booster called NMN (500 mg/d) and a “pinch” of resveratrol with breakfast.
NAD – you’ll hear this a lot
NAD is a very important chemical, naturally produced with healthy diet and exercise.
Intermittent fasting is a good diet practise. That’s why I skip breakfast, sometimes.
NAD is needed for sirtuins to perform some kind of rejuvenation.
What is sirtuins?
Sirtuins is an enzyme, protecting against disease and deterioration.
It is one of the 3 longevity pathways along with mTOR and AMPK.
Sirtuins are also switched on by cold, which in turn activates protective brown fat in our back and shoulders. This is why there is cold therapy. I don’t go to that extend, but I switch from hot to cold at the end of every shower.
Body internal age
Measure your body internal age with a blood test by InsideTracker.
It analyses blood biomarkers such as glucose, Vitamin D, etc.
Blood glucose level is probably the most important biomarker.
Specifically, studies suggest that whether a person will live longer or shorter than average can be predicted by measuring fasting glucose.
Fasting blood sugar test is measuring a blood sample after an overnight fast. A fasting blood sugar level is:
- Normal if < 100 mg/dL (5.6 mmol/L)
- Prediabetes if 100-125 mg/dL (5.6-6.9 mmol/L)
- Diabetes if > 126 mg/dL (7 mmol/L)
Oh, I have a blood glucose reader at home. How convenient to take measurements.
More Resources
- Association between fasting glucose and mortality
- InsideTracker scientific report
- 23andme for your DNA sequencing
- From another guy who knows how to live longer: Dr Peter Attia and his interview with Joe Rogan
- Ben Greenfield is not a fan of metformin, instead suggested ways to control blood sugar
- David Sinclair’s Lifespan newsletter